Smith M-C, Gueux A, Coton M, Madec S, Hymery N, Coton E. 2018b. In vitro co-culture models to evaluate acute toxicity of individual and combined mycotoxin exposures on the human cell lines THP-1, HepaRG and Caco-2. Chemico-Biological Interactions, 281: 51-59.
https://www.ncbi.nlm.nih.gov/pubmed/29222052
Dans une démarche éthique visant à réduire l’expérimentation animale, de nombreuses études de toxicologie sont aujourd’hui menées sur des systèmes in vitro afin d’élaborer ses solutions alternatives. Il semblait donc intéressant de développer un modèle in vitro plus complexe utilisant les trois modèles cellulaires HepaRG (hépatocytes) , Caco-2 (cellules épithéliales intestinales) et THP-1 (monocytes) afin de mieux comprendre les effets du couple de mycotoxines DON/ZEA sur ces interactions cellulaires. Les résultats montrent que la complexité du modèle cellulaire rend moins vulnérable les cellules aux mycotoxines. Ils soulignent l’existence d’interactions potentielles entre les différents types cellulaires faisant surement intervenir différents médiateurs chimiques. Ces interactions modifient la réponse cellulaire aux mycotoxines. Il existe donc aujourd’hui tout un champ d’investigation possible pour mimer plus finement la complexité de l’in vivo et permettre une évaluation plus précise du risque «mycotoxines» pour la santé humaine et animale.
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