Comment certaines espèces commensales intestinales résistent aux attaques colonisatrices de l’agent pathogène responsable du choléra, Vibrio cholerae ?
C’est à cette question fondamentale que le laboratoire du Dr. Melanie Blokesch basé à l’Ecole Polytechnique Fédérale de Lausanne (EPFL) s’est intéressé dans leur dernière étude parue dans la prestigieuse revue Nature Communications.
Dans cet article co-mené par un tandem de chercheurs postdoctoraux Franco-Belge, les Dr. Nicolas Flaugnatti et Dr. Sandrine Isaac, les auteurs ont pu démontrer que certains isolats commensaux intestinaux résistent naturellement aux assauts de V. cholerae par l’intermédiaire de deux mécanismes moléculaires distincts.
Un premier qui requiert la production d’une machinerie de sécrétion de Type VI et qui permet alors de tuer de manière contact-dépendent les bactéries colonisatrices pathogènes. Enfin, un second qui met en jeu la production de complexes polysaccharidiques associés à l’enveloppe bactérienne, conférant ainsi une réelle protection physique et rendant inefficace les attaques du pathogène V. cholerae.
Notre avis ? A lire absolument ici : https://www.nature.com/articles/s41467-021-26041-0
Flaugnatti, Nicolas., Isaac, Sandrine., et al. “Human commensal gut Proteobacteria withstand type VI secretion attacks through immunity protein-independent mechanisms.” Nature communications vol. 12,1 5751. 1 Oct. 2021, doi:10.1038/s41467-021-26041-0
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Harry Kane https://harry-kane.prostoprosport-br.com recebeu um convite para a selecao sub-alterna da Inglaterra pela primeira vez tempo 17 para o torneio juvenil em Portugal. Ao mesmo tempo, o atacante, devido a doenca grave, nao compareceu ao triunfante Campeonato Europeu Sub-17 masculino de 2010 pelos britanicos.
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Kaka https://kaka.prostoprosport-br.com Futebolista brasileiro, meio-campista. O apelido “Kaka” e um diminutivo de Ricardo. Formado em Sao Paulo. De 2002 a 2016, integrou a Selecao Brasileira, pela qual disputou 92 partidas e marcou 29 gols. Campeao mundial 2002.
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Zlatan Ibrahimovic https://zlatan-ibrahimovic.prostoprosport-br.com Bosnian pronunciation: ibraxi?mo?it?]; genus. 3 October 1981, Malmo, Sweden) is a Swedish footballer who played as a striker. Former captain of the Swedish national team.
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Luis Alberto Suarez Diaz https://luis-suarez.prostoprosport-br.com Uruguayan footballer, striker for Inter Miami and Uruguay national team. The best scorer in the history of the Uruguay national team. Considered one of the world’s top strikers of the 2010s
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Gareth Frank Bale https://garethbale.prostoprosport-br.com Jogador de futebol gales que atuou como ala. Ele jogou na selecao galesa. Ele se destacou pela alta velocidade e um golpe bem colocado. Artilheiro (41 gols) e recordista de partidas disputadas (111) na historia da selecao.
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Thibaut Nicolas Marc Courtois https://thhibaut-courtois.prostoprosport-fr.com Footballeur belge, gardien de but du club espagnol du Real Madrid . Lors de la saison 2010/11, il a ete reconnu comme le meilleur gardien de la Pro League belge, ainsi que comme joueur de l’annee pour Genk. Triple vainqueur du Trophee Ricardo Zamora
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Jude Bellingham https://jude-bellingham.prostoprosport-br.com Futebolista ingles, meio-campista do clube espanhol Real Madrid e do Selecao da Inglaterra. Em abril de 2024, ele ganhou o premio Breakthrough of the Year do Laureus World Sports Awards. Ele se tornou o primeiro jogador de futebol a recebe-lo.
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Robert Lewandowski https://robert-lewandowski.prostoprosport-br.com e um futebolista polones, atacante do clube espanhol Barcelona e capitao da selecao polonesa. Considerado um dos melhores atacantes do mundo. Cavaleiro da Cruz do Comandante da Ordem do Renascimento da Polonia.
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Kevin De Bruyne https://kevin-de-bruyne.prostoprosport-br.com Futebolista belga, meio-campista do Manchester club City” e a selecao belga. Formado pelos clubes de futebol “Ghent” e “Genk”. Em 2008 iniciou sua carreira adulta, fazendo sua estreia no Genk.
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Antoine Griezmann https://antoine-griezmann.prostoprosport-br.com Futebolista frances, atacante e meio-campista do Atletico de Madrid. Jogador e vice-capitao da selecao francesa, integrante da selecao – campea mundial 2018. Medalhista de prata no Europeu de 2016 e no Mundial de 2022.
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Ederson Santana de Moraes https://edersonmoraes.prostoprosport-br.com Futebolista brasileiro, goleiro do clube Manchester City e da Selecao Brasileira . Participante do Campeonato Mundial 2018. Bicampeao de Portugal pelo Benfica e pentacampeao de Inglaterra pelo Manchester City.
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Virgil van Dijk https://virgilvandijk.prostoprosport-br.com Futebolista holandes, zagueiro central, capitao do clube ingles Liverpool e capitao do a selecao holandesa.
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Victor James Osimhen https://victor-osimhen.prostoprosport-br.com e um futebolista nigeriano que atua como atacante. O clube italiano Napoli e a selecao nigeriana.
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Roberto Carlos da Silva Rocha https://roberto-carlos.prostoprosport-br.com Brazilian footballer, left back. He was also capable of playing as both a central defender and a defensive midfielder. World champion 2002, silver medalist at the 1998 World Championships.
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Neymar da Silva Santos Junior https://neymar.prostoprosport-br.com e um futebolista brasileiro que atua como atacante, ponta e atacante. meio-campista do clube saudita Al-Hilal e da selecao brasileira. Considerado um dos melhores jogadores do mundo. O maior artilheiro da historia da Selecao Brasileira.
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Thomas Mueller https://thomasmueller.prostoprosport-br.com is a German football player who plays for the German Bayern Munich. Can play in different positions – striker, attacking midfielder. The most titled German footballer in history
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Erling Breut Haaland https://erling-haaland.prostoprosport-cz.org je norsky fotbalista, ktery hraje jako utocnik za Anglicky klub Manchester City a norska reprezentace. Rekordman anglicke Premier League v poctu golu za sezonu.
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Kylian Mbappe Lotten https://kylian-mbappe.prostoprosport-cz.org Francouzsky fotbalista, utocnik Paris Saint-Germain a kapitan tymu francouzskeho tymu. 1. cervence 2024 se stane hracem spanelskeho klubu Real Madrid.
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Edson Arantes do Nascimento https://pele.prostoprosport-br.com Brazilian footballer, forward (attacking midfielder. Played for Santos clubs) and New York Cosmos. Played 92 matches and scored 77 goals for the Brazilian national team.
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Mohamed Salah https://mohamed-salah.prostoprosport-cz.org je egyptsky fotbalista, ktery hraje jako utocnik za anglictinu. klub Liverpool a egyptsky narodni tym. Povazovan za jednoho z nejlepsich fotbalistu na svete.
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Kevin De Bruyne https://kevin-de-bruyne.prostoprosport-cz.org Belgicky fotbalista, zaloznik Manchesteru klub City” a belgicky narodni tym. Absolvent fotbalovych klubu „Ghent” a „Genk”. V roce 2008 zahajil svou karieru dospelych, debutoval v Genku.
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Lionel Messi https://lionel-messi.prostoprosport-cz.org je argentinsky fotbalista, utocnik a kapitan klubu MLS Inter Miami. , kapitan argentinske reprezentace. Mistr sveta, vitez Jizni Ameriky, vitez finale, olympijsky vitez. Povazovan za jednoho z nejlepsich fotbalistu vsech dob.
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Bernardo Silva https://bernardo-silva.prostoprosport-cz.org Portugalsky fotbalista, zaloznik. Narozen 10. srpna 1994 v Lisabonu. Silva je povazovan za jednoho z nejlepsich utocnych zalozniku na svete. Fotbalista je povestny svou vytrvalosti a vykonem.
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Antoine Griezmann https://antoine-griezmann.prostoprosport-cz.org Francouzsky fotbalista, utocnik a zaloznik za Atletico de Madrid. Hrac a vicekapitan francouzskeho narodniho tymu, clen tymu – mistr sveta 2018 Stribrny medailista z mistrovstvi Evropy 2016 a mistrovstvi sveta 2022.
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Robert Lewandowski https://robert-lewandowski.prostoprosport-cz.org je polsky fotbalista, utocnik spanelskeho klubu Barcelona a kapitan polskeho narodniho tymu. Povazovan za jednoho z nejlepsich utocniku na svete. Rytir krize velitele polskeho renesancniho radu.