Ce mois-ci, notre article coup de coeur est à propos de Myxococcus xanthus, et a été publié en Janvier 2023 :
A Diverged Transcriptional Network for Usage of Two Fe-S Cluster Biogenesis Machineries in the Delta-Proteobacterium Myxococcus xanthus
Ici, il est présenté un exemple de la manière dont une bactérie de la branche des Deltaproteobacteria coordonne l’expression de deux machineries de biogénèse des grappes Fe-S. Les résultats révèlent ainsi un nouveau modèle de coordination de la biogénèse des grappes Fe-S, soulignant les caractéristiques uniques et communes qui ont émergé indépendamment chez des bactéries phylogénétiquement éloignées pour maintenir l’homéostasie des clusters Fe-S en réponse à des changements environnementaux. La régulation est orchestrée par un régulateur transcriptionnel non caractérisé auparavant, RisR, appartenant à la superfamille Rrf2, dont les membres sont connus pour détecter divers stress environnementaux fréquemment rencontrés par les bactéries. Comprendre comment M. xanthus maintient l’homéostasie des amas Fe-S via la régulation RisR a révélé une stratégie reflétant le mode de vie aérobie de cet organisme. Ces nouvelles connaissances ouvrent également la voie à l’amélioration de la production de métabolites secondaires Fe-S-dépendants en utilisant M. xanthus comme châssis.
Myxococcus xanthus possède en effet deux machineries de biogenèse des clusters Fe-S, ISC (cluster fer-soufre) et SUF (mobilisation du soufre). Il est montré dans cet article que par rapport aux entérobactéries phylogénétiquement éloignées, qui possèdent également les deux machineries, M. xanthus a développé un schéma transcriptionnel indépendant pour réguler de manière coordonnée l’expression de ces machineries. Cette réponse transcriptionnelle est dirigée par RisR, qui appartient à un sous-groupe phylogénétiquement distant et biochimiquement distinct de la famille des facteurs de transcription Rrf2, en comparaison avec IscR qui régule les opérons isc et suf chez les entérobactéries. Ainsi, RisR héberge un cluster Fe-S et holo-RisR agit comme un répresseur des opérons isc et suf, contrairement à Escherichia coli, où holo-IscR réprime l’opéron isc tandis que apo-IscR active l’opéron suf. Cet article établit que la nature du cluster et les sites de liaison à l’ADN de RisR, dans les opérons isc et suf, divergent de ceux d’IscR. Egalement, chez M. xanthus, les deux machineries semblent être totalement interchangeables dans le maintien des niveaux de biogénèse des clusters Fe-S et dans la synthèse du cluster Fe-S pour leur régulateur commun, RisR. De plus, en réponse au stress oxydatif et à la limitation en fer, l’augmentation transcriptionnelle des opérons isc et suf de M. xanthus était uniquement médiée par RisR et la contribution de la machinerie SUF était plus importante que celle de la machinerie ISC.
Etant donné que les protéines Fe-S sont devenues des enzymes clés dans la production/modification de métabolites et en considérant le besoin croissant de nouveaux antimicrobiens, cette étude ouvre la voie à l’amélioration de la biosynthèse à l’échelle industrielle de molécules dépendant de la grappe Fe-S chez M. xanthus
Retrouvez l’article complet ici ?
Orxdgz
buy generic atorvastatin 10mg atorvastatin online buy lipitor generic
Vinbva
buy propecia without a prescription purchase finasteride pills forcan for sale online
Rylpto
ciprofloxacin online order – cipro 1000mg sale augmentin 1000mg pill
Touywa
cipro 1000mg tablet – brand ciprofloxacin where can i buy clavulanate
Oxvshz
order flagyl 200mg without prescription – cleocin us buy azithromycin 250mg online cheap
Tfjrdg
buy ciplox – ciplox 500mg usa erythromycin oral
Rynksb
buy valtrex pill – order nateglinide for sale buy zovirax 400mg pills
Jbkuxv
stromectol human – buy ciprofloxacin 500 mg pill where can i buy tetracycline
Kjdjmd
order metronidazole 400mg pills – flagyl pills order generic zithromax 250mg
Kzoidl
buy ampicillin pill buy amoxicillin tablets order amoxil generic
Qjtkai
order lasix 40mg pill – buy minipress 2mg sale capoten 120mg cheap
Ydletv
buy glycomet pills – buy lincocin 500mg without prescription lincocin oral
Lnkytu
cost zidovudine 300mg – buy irbesartan 150mg online cheap buy allopurinol no prescription
Tfhmik
buy generic clozapine 100mg – order perindopril 4mg pills pepcid 20mg without prescription
Vqayod
buy seroquel 50mg without prescription – eskalith tablets eskalith over the counter
Mnpplt
purchase clomipramine – doxepin usa sinequan canada
Tzbjjr
hydroxyzine 25mg oral – cost nortriptyline 25 mg oral endep 25mg
Ghrtqk
buy augmentin 1000mg without prescription – buy bactrim without prescription buy cipro 1000mg sale
Qfabay
buy amoxicillin online cheap – order ceftin 500mg for sale ciprofloxacin 1000mg over the counter
Zfxekq
buy cleocin 150mg pill – oxytetracycline brand brand chloromycetin
Leldiw
azithromycin 500mg canada – azithromycin us ciplox buy online
Gnkjjc
ivermectin pills for humans – order eryc cost cefaclor 250mg
Klcvhg
albuterol inhalator sale – buy cheap theophylline buy cheap generic theo-24 Cr
Wavtfp
order medrol pill – methylprednisolone 16 mg oral azelastine 10ml usa
Niuozi
clarinex 5mg oral – triamcinolone 10mg over the counter albuterol inhalator for sale online
Bdlinm
purchase micronase without prescription – pioglitazone ca forxiga 10 mg price
Pbznbc
repaglinide 2mg ca – empagliflozin brand empagliflozin 10mg pills
Spkkpm
glucophage 1000mg pill – januvia 100 mg drug order acarbose 25mg online cheap
Xrurqj
order generic rybelsus – glucovance pills DDAVP online buy
Nwawqx
buy nizoral 200mg online cheap – ketoconazole pills order sporanox 100 mg pills
Jtkanp
order famciclovir 250mg generic – purchase valcivir pills generic valaciclovir
Zkzxzh
digoxin 250 mg usa – dipyridamole buy online buy lasix
Kzvttl
buy hydrochlorothiazide 25mg without prescription – hydrochlorothiazide without prescription bisoprolol 10mg generic
Tawmbf
buy viagra professional probable – cialis professional plant levitra oral jelly soil
Arfwah
cialis soft tabs regard – caverta thorough viagra oral jelly online tin
Zxufcv
acne treatment sway – acne treatment building acne treatment skin
prodvizhen_mlPn
сео продвижение prodvizhenie-sajtov15.ru .
Ihmpfj
ascorbic acid assemble – ascorbic acid whistle ascorbic acid why
Matras_qhpn
matras bestellen http://www.kupit-matras111.ru/ .
Vfwxai
biaxin wind – asacol bank cytotec pills treasure
Xbetik
fludrocortisone pills ignore – esomeprazole pills bag lansoprazole anxious
Seo_acOt
качественное продвижение сайтов http://prodvizhenie-sajtov-v-moskve111.ru .
Qkfjzp
order dulcolax pills – oxybutynin 5mg cheap liv52 price
Ohetcw
aciphex 20mg usa – buy generic metoclopramide online buy domperidone 10mg online
Anal_yyMr
русский анал видео https://russkiy-anal-x.ru .
Lakidjet_loMl
лаки джет официальный сайт лаки джет официальный сайт .
Moshenniki_wmoi
куда пожаловаться на сайт мошенников http://www.pozhalovatsya-na-moshennikov.ru .
Hgzwzu
buy generic hydroquinone over the counter – dydrogesterone 10 mg uk brand dydrogesterone 10mg
Psfdqc
forxiga online order – generic sinequan 25mg acarbose drug
Xhxxlv
fulvicin 250 mg usa – order dipyridamole generic lopid price
Tvspox
purchase dimenhydrinate – buy dramamine online cheap buy risedronate 35mg for sale
Gates_of_Olympu_bzKn
gates of olympus играть gates of olympus играть .
Wffvgb
generic etodolac 600mg – buy cheap generic pletal cost cilostazol
sweetbonanza_ylMl
свит бонанза свит бонанза .
Eskmiq
buy feldene medication – order exelon 3mg for sale exelon online order
crazymonkey_emSi
крейзи манки крейзи манки .
TimsothyTet
Ежегодно в середине сентября проходит Тюменский инновационный форум «НЕФТЬГАЗТЭК».
Форум посвящен определению мнтодов инноваторского развития областей топливно-энергетического комплекса, дискуссии а также определению заключений, организации наилучших условий для расчета инновационных проектов. Ежегодный тюменский форум представляетсобой авторитетной дискуссионной площадкой по продвижению нефтегазовой сферы в Российской Федерации, содержит высокий авторитет и актуальность, созвучен общей стратегии формирования инноваторского курса в России
-https://neftgaztek.ru/
anal_rbkt
русский анал с разговорами бесплатно русский анал с разговорами бесплатно .
Dichaelsop
Ежегодно в середине сентября проходит Тюменский инновационный форум «НЕФТЬГАЗТЭК».
Форум посвящен устройству мнтодов инновационного роста секторов топливно-энергетического комплекса, дискуссии и определению решений, организации благоприятных условий для развития инновационных проектов. Ежегодный тюменский форум является авторитетной дискуссионной площадкой по развитию нефтегазовой отрасли в России, имеет высокий статус и своевременность, созвучен корпоративной стратегии продвижения инноваторского направления в России
https://neftgaztek.ru/
Diplomi_hvmi
купить диплом о среднем образовании https://school5-priozersk.ru/ .
jirosjigatel_jeor
жиросжигатель купить http://www.ozon.ru/product/nexis-effektivnye-tabletki-dlya-pohudeniya-zhiroszhigatel-dlya-zhenshchin-60-kapsul-kurs-na-mesyats-1564574748/ .
Diplomi_hlPl
купить диплом фармацевта цена купить диплом фармацевта цена .
semarak
A cool post there mate ! Thank you for posting.
AlbertVof
pin-up 306 https://azerbaijancuisine.com/# pin-up casino giris
pin up az?rbaycan
Larrynub
pin up azerbaycan: pin up azerbaycan yukle – pin-up
Stcyuu
nootropil 800 mg pill – brand praziquantel order sinemet online cheap
Saiti_vpsa
продвижение сайтов по москве в топ продвижение сайтов по москве в топ .
santosa
Awesome post. It’s so good to see someone taking the time to share this information
Zkqcot
buy hydrea generic – order trental generic methocarbamol 500mg over the counter
Williamadvam
pharmacies in mexico that ship to usa: northern doctors – п»їbest mexican online pharmacies
Jeffreymycle
http://northern-doctors.org/# buying prescription drugs in mexico online
RichardJeave
п»їbest mexican online pharmacies mexican northern doctors mexico drug stores pharmacies
Jeffreymycle
https://northern-doctors.org/# mexican pharmaceuticals online
Williamadvam
mexican border pharmacies shipping to usa: mexican pharmacy northern doctors – best online pharmacies in mexico
Jeffreymycle
https://northern-doctors.org/# mexico drug stores pharmacies
Jeffreymycle
https://northern-doctors.org/# buying prescription drugs in mexico
Williamadvam
п»їbest mexican online pharmacies: northern doctors pharmacy – buying prescription drugs in mexico online
RichardJeave
reputable mexican pharmacies online mexican drugstore online mexican rx online
Williamadvam
buying from online mexican pharmacy: mexican pharmacy – mexico drug stores pharmacies
Jeffreymycle
http://northern-doctors.org/# mexican mail order pharmacies
RichardJeave
mexico drug stores pharmacies northern doctors reputable mexican pharmacies online
Diplom_oeer
купить диплом в кисловодске [url=https://vm-tver.ru/]купить диплом в кисловодске[/url] .
Jeffreymycle
https://northern-doctors.org/# mexican rx online
Williamadvam
purple pharmacy mexico price list: mexican northern doctors – mexico pharmacies prescription drugs
Jeffreymycle
https://northern-doctors.org/# mexico drug stores pharmacies
Williamadvam
medicine in mexico pharmacies: mexican northern doctors – mexican online pharmacies prescription drugs
Jeffreymycle
http://northern-doctors.org/# mexican pharmacy
RichardJeave
buying prescription drugs in mexico online mexican northern doctors п»їbest mexican online pharmacies
Jeffreymycle
https://northern-doctors.org/# medication from mexico pharmacy
Williamadvam
mexican pharmaceuticals online: northern doctors pharmacy – mexico drug stores pharmacies
Williamadvam
medicine in mexico pharmacies: mexican pharmacy northern doctors – reputable mexican pharmacies online
Williamadvam
pharmacies in mexico that ship to usa: mexican pharmacy – buying from online mexican pharmacy
Williamadvam
mexico pharmacies prescription drugs: mexican border pharmacies shipping to usa – mexican pharmacy
Jeffreymycle
https://northern-doctors.org/# pharmacies in mexico that ship to usa
Williamadvam
buying prescription drugs in mexico: mexican pharmacy northern doctors – mexican border pharmacies shipping to usa
Williamadvam
mexican pharmacy: mexican pharmacy northern doctors – mexican drugstore online
Jeffreymycle
https://northern-doctors.org/# pharmacies in mexico that ship to usa
Pereezd_jeml
переезд минск переезд минск .
Williamadvam
purple pharmacy mexico price list: mexican pharmacy – mexican mail order pharmacies
RichardJeave
mexican drugstore online northern doctors pharmacy best online pharmacies in mexico
Jeffreymycle
http://northern-doctors.org/# mexico pharmacy
Williamadvam
mexico pharmacies prescription drugs: mexican pharmaceuticals online – mexican border pharmacies shipping to usa
Williamadvam
mexican online pharmacies prescription drugs: Mexico pharmacy that ship to usa – mexican online pharmacies prescription drugs
Jeffreymycle
http://northern-doctors.org/# best online pharmacies in mexico
Williamadvam
buying from online mexican pharmacy: mexican pharmacy – reputable mexican pharmacies online
Williamadvam
mexico pharmacies prescription drugs: northern doctors pharmacy – mexico drug stores pharmacies
Jeffreymycle
https://northern-doctors.org/# medicine in mexico pharmacies
Williamadvam
buying prescription drugs in mexico online: northern doctors pharmacy – buying from online mexican pharmacy
Jeffreymycle
https://northern-doctors.org/# medicine in mexico pharmacies
Williamadvam
best online pharmacies in mexico: mexican northern doctors – mexican rx online
RichardJeave
mexican drugstore online mexican border pharmacies shipping to usa medicine in mexico pharmacies
Williamadvam
mexico drug stores pharmacies: mexican pharmacy – buying from online mexican pharmacy
Jeffreymycle
https://northern-doctors.org/# mexican drugstore online
Williamadvam
mexico pharmacy: Mexico pharmacy that ship to usa – best online pharmacies in mexico
Jeffreymycle
https://northern-doctors.org/# mexican mail order pharmacies
Williamadvam
п»їbest mexican online pharmacies: Mexico pharmacy that ship to usa – mexican pharmaceuticals online
Williamadvam
buying from online mexican pharmacy: northern doctors – mexican online pharmacies prescription drugs
Jeffreymycle
https://northern-doctors.org/# mexican pharmaceuticals online
Williamadvam
reputable mexican pharmacies online: northern doctors – mexican rx online
RichardJeave
purple pharmacy mexico price list northern doctors pharmacy mexico pharmacies prescription drugs
Williamadvam
mexican drugstore online: mexican pharmacy northern doctors – medication from mexico pharmacy
Williamadvam
mexican drugstore online: Mexico pharmacy that ship to usa – п»їbest mexican online pharmacies
Jeffreyrig
http://cmqpharma.com/# mexico pharmacies prescription drugs
reputable mexican pharmacies online
Ronniesig
mexican drugstore online mexican pharmacy online best online pharmacies in mexico
StephenLob
purple pharmacy mexico price list: cmq pharma – buying from online mexican pharmacy
Ronniesig
mexico pharmacies prescription drugs online mexican pharmacy best online pharmacies in mexico
Iyenrq
divalproex buy online – mefloquine us order topamax 100mg without prescription
Ronniesig
п»їbest mexican online pharmacies cmq pharma buying prescription drugs in mexico online
Ronniesig
mexican rx online cmqpharma.com pharmacies in mexico that ship to usa
Ronniesig
mexico drug stores pharmacies cmq mexican pharmacy online reputable mexican pharmacies online
Donaldfrono
best online pharmacies in mexico
https://cmqpharma.com/# buying prescription drugs in mexico online
mexican border pharmacies shipping to usa
Ronniesig
purple pharmacy mexico price list cmqpharma.com mexican pharmacy
Ronniesig
reputable mexican pharmacies online mexican pharmacy online reputable mexican pharmacies online
Hcdbbg
buy disopyramide phosphate online cheap – norpace online buy thorazine 50 mg generic
Jeffreyrig
https://cmqpharma.online/# mexico drug stores pharmacies
mexico drug stores pharmacies
Ronniesig
п»їbest mexican online pharmacies mexican pharmacy reputable mexican pharmacies online
Tyvmeh
cytoxan tablet – buy meclizine pills buy trimetazidine pill
DonaldCusty
Профессиональные seo https://seo-optimizaciya-kazan.ru услуги для максимизации онлайн-видимости вашего бизнеса. Наши эксперты проведут глубокий анализ сайта, оптимизируют контент и структуру, улучшат технические аспекты и разработают индивидуальные стратегии продвижения.
Ftvuns
aldactone 100mg cost – buy dilantin 100 mg pill order naltrexone generic